USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: ITA2B_HUMAN USC-OGP 2-DE database:  ITA2B_HUMAN ITA2B_HUMAN General information about the entry View entry in simple text format Entry name ITA2B_HUMAN Primary accession number P08514 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Integrin alpha-IIb; AltName: Full=GPalpha IIb; Short=GPIIb; AltName: Full=Platelet membrane glycoprotein IIb; AltName: CD_antigen=CD41; Contains: RecName: Full=Integrin alpha-IIb heavy chain; Contains: RecName: Full=Integrin alpha-IIb light chain, form 1; Contains: RecName: Full=Integrin alpha-IIb light chain, form 2; Flags: Precursor;. Gene name Name=ITGA2B Synonyms=GP2B, ITGAB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0001: pI=4.69; Mw=135464 SPOT OGP-0002: pI=4.70; Mw=134033 SPOT OGP-0003: pI=4.72; Mw=134033 SPOT OGP-0004: pI=4.80; Mw=132617 SPOT OGP-0005: pI=4.75; Mw=131915 SPOT OGP-0006: pI=4.84; Mw=131915 SPOT OGP-0007: pI=4.94; Mw=131915 SPOT OGP-0008: pI=4.99; Mw=131915 SPOT OGP-0009: pI=4.87; Mw=131217 SPOT OGP-0010: pI=4.90; Mw=131217 SPOT OGP-0011: pI=5.01; Mw=130522 SPOT OGP-0034: pI=4.81; Mw=67021 SPOT OGP-0035: pI=4.86; Mw=66737 SPOT OGP-0036: pI=4.84; Mw=66455 SPOT OGP-0041: pI=4.69; Mw=60921 SPOT OGP-0054: pI=4.66; Mw=55042 SPOT OGP-0055: pI=4.69; Mw=54800 Cross-references UniProtKB/Swiss-Prot P08514; ITA2B_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ITA2B_HUMAN Primary accession number P08514 Secondary accession number(s) B2RCY8 O95366 Q14443 Q17R67 Sequence was last modified on  April 14, 2009 (version 3) Annotations were last modified on  March 15, 2017 (version 215) Name and origin of the protein Description RecName: Full=Integrin alpha-IIb; AltName: Full=GPalpha IIb; Short=GPIIb; AltName: Full=Platelet membrane glycoprotein IIb; AltName: CD_antigen=CD41; Contains: RecName: Full=Integrin alpha-IIb heavy chain; Contains: RecName: Full=Integrin alpha-IIb light chain, form 1; Contains: RecName: Full=Integrin alpha-IIb light chain, form 2; Flags: Precursor; Gene name Name=ITGA2B Synonyms=GP2B, ITGAB Encoded on Name=ITGA2B; Synonyms=GP2B, ITGAB Keywords 3D-structure; Alternative splicing; Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Polymorphism; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J02764; AAA60114.1; -; mRNA EMBL M34480; AAA35926.1; -; mRNA EMBL M34344; AAA53150.1; -; Genomic_DNA EMBL M33319; AAA53150.1; JOINED; Genomic_DNA EMBL M33320; AAA53150.1; JOINED; Genomic_DNA EMBL M54799; AAA52599.1; -; Genomic_DNA EMBL X06831; CAA29987.1; -; mRNA EMBL M18085; AAA52597.1; -; mRNA EMBL M22568; AAA52587.1; -; Genomic_DNA EMBL M22569; AAA52588.1; -; Genomic_DNA EMBL AF098114; AAC98507.1; -; mRNA EMBL AK315335; BAG37735.1; -; mRNA EMBL AC003043; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC117443; AAI17444.1; -; mRNA EMBL BC126442; AAI26443.1; -; mRNA CCDS CCDS32665.1; -. [P08514-1]; . PIR A34269; A34269; . RefSeq NP_000410.2; NM_000419.4. [P08514-1]; . RefSeq XP_011523051.1; XM_011524749.1. [P08514-2]; . UniGene Hs.411312; -; . PDB 1DPK; NMR; -; A=1020-1039 PDB 1DPQ; NMR; -; A=1020-1039 PDB 1JX5; Model; -; A=32-483 PDB 1KUP; NMR; -; A=1018-1028 PDB 1KUZ; NMR; -; A=1018-1028 PDB 1M8O; NMR; -; A=1020-1039 PDB 1RN0; Model; -; A=32-482 PDB 1S4W; NMR; -; A=1020-1039 PDB 1TYE; X-ray; 2.90 A; A/C/E=32-483 PDB 1UV9; Model; -; A=32-973 PDB 2K1A; NMR; -; A=989-1029 PDB 2K9J; NMR; -; A=989-1029 PDB 2KNC; NMR; -; A=991-1039 PDB 2MTP; NMR; -; B=1019-1039 PDB 2N9Y; NMR; -; A=989-1029 PDB 2VC2; X-ray; 3.10 A; A=32-483 PDB 2VDK; X-ray; 2.80 A; A=32-483 PDB 2VDL; X-ray; 2.75 A; A=32-483 PDB 2VDM; X-ray; 2.90 A; A=32-483 PDB 2VDN; X-ray; 2.90 A; A=32-483 PDB 2VDO; X-ray; 2.51 A; A=32-483 PDB 2VDP; X-ray; 2.80 A; A=32-483 PDB 2VDQ; X-ray; 2.59 A; A=32-483 PDB 2VDR; X-ray; 2.40 A; A=32-483 PDB 3FCS; X-ray; 2.55 A; A/C=32-989 PDB 3FCU; X-ray; 2.90 A; A/C/E=32-488 PDB 3NID; X-ray; 2.30 A; A/C=32-488 PDB 3NIF; X-ray; 2.40 A; A/C=32-488 PDB 3NIG; X-ray; 2.25 A; A/C=32-488 PDB 3T3M; X-ray; 2.60 A; A/C=32-488 PDB 3T3P; X-ray; 2.20 A; A/C=32-488 PDB 3ZDX; X-ray; 2.45 A; A/C=32-488 PDB 3ZDY; X-ray; 2.45 A; A/C=32-488 PDB 3ZDZ; X-ray; 2.75 A; A/C=32-488 PDB 3ZE0; X-ray; 2.95 A; A/C=32-488 PDB 3ZE1; X-ray; 3.00 A; A/C=32-488 PDB 3ZE2; X-ray; 2.35 A; A/C=32-488 PDB 4CAK; EM; 20.50 A; A=32-989 PDB 4Z7N; X-ray; 2.60 A; A/C=32-486 PDB 4Z7O; X-ray; 2.85 A; A/C=32-486 PDB 4Z7Q; X-ray; 2.70 A; A/C=32-485 PDB 5HDB; X-ray; 2.70 A; A/C=32-485 PDBsum 1DPK; -; . PDBsum 1DPQ; -; . PDBsum 1JX5; -; . PDBsum 1KUP; -; . PDBsum 1KUZ; -; . PDBsum 1M8O; -; . PDBsum 1RN0; -; . PDBsum 1S4W; -; . PDBsum 1TYE; -; . PDBsum 1UV9; -; . PDBsum 2K1A; -; . PDBsum 2K9J; -; . PDBsum 2KNC; -; . PDBsum 2MTP; -; . PDBsum 2N9Y; -; . PDBsum 2VC2; -; . PDBsum 2VDK; -; . PDBsum 2VDL; -; . PDBsum 2VDM; -; . PDBsum 2VDN; -; . PDBsum 2VDO; -; . PDBsum 2VDP; -; . PDBsum 2VDQ; -; . PDBsum 2VDR; -; . PDBsum 3FCS; -; . PDBsum 3FCU; -; . PDBsum 3NID; -; . PDBsum 3NIF; -; . PDBsum 3NIG; -; . PDBsum 3T3M; -; . PDBsum 3T3P; -; . PDBsum 3ZDX; -; . PDBsum 3ZDY; -; . PDBsum 3ZDZ; -; . PDBsum 3ZE0; -; . PDBsum 3ZE1; -; . PDBsum 3ZE2; -; . PDBsum 4CAK; -; . PDBsum 4Z7N; -; . PDBsum 4Z7O; -; . PDBsum 4Z7Q; -; . PDBsum 5HDB; -; . ProteinModelPortal P08514; -; . SMR P08514; -; . BioGrid 109881; 13; . DIP DIP-68N; -; . IntAct P08514; 2; . STRING 9606.ENSP00000262407; -; . BindingDB P08514; -; . ChEMBL CHEMBL212; -; . DrugBank DB00054; Abciximab; . DrugBank DB04863; Lefradafiban; . DrugBank DB00775; Tirofiban; . GuidetoPHARMACOLOGY 2440; -; . iPTMnet P08514; -; . PhosphoSitePlus P08514; -; . BioMuta ITGA2B; -; . DMDM 226694183; -; . OGP P08514; -; . PaxDb P08514; -; . PeptideAtlas P08514; -; . PRIDE P08514; -; . TopDownProteomics P08514-1; -. [P08514-1]; . Ensembl ENST00000262407; ENSP00000262407; ENSG00000005961. [P08514-1]; . GeneID 3674; -; . KEGG hsa:3674; -; . UCSC uc002igt.2; human. [P08514-1]; . CTD 3674; -; . DisGeNET 3674; -; . GeneCards ITGA2B; -; . HGNC HGNC:6138; ITGA2B; . HPA CAB018611; -; . HPA HPA031168; -; . HPA HPA031169; -; . HPA HPA031170; -; . HPA HPA031171; -; . MalaCards ITGA2B; -; . MIM 187800; phenotype; . MIM 273800; phenotype; . MIM 607759; gene; . neXtProt NX_P08514; -; . OpenTargets ENSG00000005961; -; . Orphanet 140957; Autosomal dominant macrothrombocytopenia; . Orphanet 853; Fetal and neonatal alloimmune thrombocytopenia; . Orphanet 849; Glanzmann thrombasthenia; . PharmGKB PA29938; -; . eggNOG KOG3637; Eukaryota; . eggNOG ENOG410XPVZ; LUCA; . GeneTree ENSGT00760000118782; -; . HOGENOM HOG000231603; -; . HOVERGEN HBG006186; -; . InParanoid P08514; -; . KO K06476; -; . OMA LWLLEWV; -; . OrthoDB EOG091G05Z4; -; . PhylomeDB P08514; -; . TreeFam TF105391; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-3000178; ECM proteoglycans; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-445144; Signal transduction by L1; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . SignaLink P08514; -; . ChiTaRS ITGA2B; human; . EvolutionaryTrace P08514; -; . GeneWiki ITGA2B; -; . GenomeRNAi 3674; -; . PMAP-CutDB Q17R67; -; . PRO PR:P08514; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000005961; -; . CleanEx HS_ITGA2B; -; . ExpressionAtlas P08514; baseline and differential; . Genevisible P08514; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0009897; C:external side of plasma membrane; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IEA:Ensembl; . GO GO:0005887; C:integral component of plasma membrane; TAS:ProtInc; . GO GO:0008305; C:integrin complex; IEA:InterPro; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0031092; C:platelet alpha granule membrane; TAS:Reactome; . GO GO:0050840; F:extracellular matrix binding; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0007155; P:cell adhesion; TAS:ProtInc; . GO GO:0007160; P:cell-matrix adhesion; IEA:Ensembl; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0007229; P:integrin-mediated signaling pathway; IDA:UniProtKB; . GO GO:0070527; P:platelet aggregation; IEA:Ensembl; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl; . InterPro IPR013517; FG-GAP; . InterPro IPR013519; Int_alpha_beta-p; . InterPro IPR000413; Integrin_alpha; . InterPro IPR013649; Integrin_alpha-2; . InterPro IPR018184; Integrin_alpha_C_CS; . InterPro IPR032695; Integrin_dom; . Pfam PF01839; FG-GAP; 2; . Pfam PF00357; Integrin_alpha; 1; . Pfam PF08441; Integrin_alpha2; 1; . PRINTS PR01185; INTEGRINA; . SMART SM00191; Int_alpha; 5; . SUPFAM SSF69179; SSF69179; 3; . PROSITE PS51470; FG_GAP; 7; . PROSITE PS00242; INTEGRIN_ALPHA; 1; .

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